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Novartis CEO defends $12 billion deal for Avidity as 'appropriate risk to take'

Published by Global Banking & Finance Review

Posted on October 27, 2025

3 min read

· Last updated: January 21, 2026

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Novartis CEO defends $12 billion deal for Avidity as 'appropriate risk to take'
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LONDON (Reuters) -Shares of Novartis fell 1% on Monday following news of the company's plans to acquire U.S. biotech Avidity Biosciences for about $12 billion, marking the Swiss drugmaker's largest

Novartis CEO Justifies $12 Billion Avidity Acquisition as Smart Move

Overview of Novartis' Acquisition Strategy

By Bhanvi Satija

Details of the Avidity Deal

LONDON (Reuters) -Swiss drugmaker Novartis on Monday defended its $12 billion deal to acquire Avidity Biosciences ahead of the U.S. firm getting late-stage data for its muscle disorder treatment next year, saying it was "an appropriate risk to take".

Market Reactions and Analyst Insights

On an investor call, Novartis CEO Vas Narasimhan said the deal size could have been "potentially twice as big" had the firm waited for the data to be released.

Future Implications for Novartis

Novartis announced the cash deal for Avidity at $72 per share on Sunday, representing a premium of 46% to the company's previous close. The drugmaker's shares slipped 1.5% on Monday, while Avidity's U.S. stock jumped more than 40%.

DEAL SPREE AIMED AT BOLSTERING PIPELINE

The Avidity acquisition is the second-largest biotech deal this year after Johnson & Johnson's $14.6 billion purchase of Intra-Cellular Therapies.

Analysts said it signalled a potential pickup in M&A in the biotech space, driven by lower valuations and recent drug pricing deals in the United States.

The deal is also the largest for Novartis under Narasimhan, who became CEO in 2018. It follows a $17 billion spree this year of acquisitions and licensing deals to bolster the firm's pipeline ahead of patent expirations for its top-selling heart treatment Entresto and asthma drug Xolair.

The deal will not include Avidity's early-stage cardiology programs, which are being spun off separately.

Avidity has three late-stage therapies targeting rare neuromuscular disorders. Its experimental therapy, Del-zota, for a form of Duchenne muscular dystrophy, is on track to seek FDA approval next year via an accelerated pathway.

Key data for another therapy, Del-diseran, for myotonic dystrophy, is also expected next year.

'A LITTLE BIT OUT OF THE ORDINARY'

Daniel Bolanowski, portfolio manager at Arctic Asset Management, which owns shares in both firms, said it was "a little bit out of the ordinary" for Novartis to move so early when they could have waited for the data.

"If you believe in the data so far, then the promise of these drug candidates is large enough that it absolutely makes sense," he said, however.

While analysts said Avidity's therapies are a natural fit for Novartis' rare disease portfolio, most said the price was higher than its usual bolt-on deals.

"I would still consider this to be a bolt-on for a company of our size and cash generation," outgoing CFO Harry Kirsch, who retires next year, told analysts. He said Novartis still had significant firepower for future deals.

(Reporting by Bhanvi Satija; Additional reporting by Sneha S K in Bengaluru; Editing by Susan Fenton and Jan Harvey)

Key Takeaways

  • Novartis acquires Avidity for $12 billion before late-stage data release.
  • Deal represents a 46% premium on Avidity's stock price.
  • Acquisition is part of Novartis' strategy to bolster its pipeline.
  • Analysts see potential increase in biotech M&A activity.
  • Avidity's therapies align with Novartis' rare disease focus.

Frequently Asked Questions

What is an acquisition?
An acquisition is a corporate action in which one company purchases most or all of another company's shares to gain control. It is a common strategy for growth and expansion.
What is M&A?
M&A stands for mergers and acquisitions, which are transactions where companies combine (merger) or one company purchases another (acquisition) to enhance their market position.
What is market reaction?
Market reaction refers to how investors respond to news or events affecting a company or the economy, often reflected in stock price movements.
What is a cash deal?
A cash deal is a transaction where payment is made entirely in cash, rather than through financing or stock exchanges.

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