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Hepatic Encephalopathy Market in Pharmaceutical industry | estimates US$ 355.4 Mn growth during 2021-2027

Published by Coherent Market Insights

Posted on September 15, 2021

4 min read

· Last updated: February 10, 2026

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Global Hepatic Encephalopathy Market, by Drug Class (Laxatives, L-aspartate, Antibiotics, L-aspartate and others), by Route of Administration (Oral, Rectal and Intravenous), by Distribution Channel (Hospital Pharmacies, Online Pharmacies and Retail Pharmacies,), and by Region (Latin America, Europe, Asia Pacific, North America, Africa, and Middle East). In 2020, the market is expected to be worth US$ […]

Hepatic Encephalopathy Market Expected to Grow by US$ 355.4 Mn by 2027

Global Hepatic Encephalopathy Market, by Drug Class (Laxatives, L-aspartate, Antibiotics, L-aspartate and others), by Route of Administration (Oral, Rectal and Intravenous), by Distribution Channel (Hospital Pharmacies, Online Pharmacies and Retail Pharmacies,), and by Region (Latin America, Europe, Asia Pacific, North America, Africa, and Middle East). In 2020, the market is expected to be worth US$ 355.4 million, with a CAGR of 5.3 percent during the forecast period (2020-2027).

The increasing prevalence of various risk factors such as hepatitis C and hepatic cirrhosis among the population is likely to boost the worldwide hepatic encephalopathy market growth. According to the CMAJ Open journal: 2018, the prevalence of liver cirrhosis in the Canadian population is predicted to rise due to increased incidence of hepatitis C and non-alcoholic fatty liver disease. In Canada, over 30% of the population suffers from liver disease.

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Market participants are engaged in inorganic activities such as acquisitions, which are projected to broaden product portfolios and enhance company positions in the global market. Ferring Pharmaceuticals Inc., for example, purchased Rebiotix Inc., a clinical-stage biotechnology company, in 2018. This merger brought together two healthcare firms that are dedicated to researching and understanding the human micro biome in order to develop new treatments for patients.

Impact of Coronavirus (COVID – 19) Pandemic:

The global hepatic encephalopathy market is projected to be slowed by the COVID-19 pandemic. The majority of individuals suffering from significant liver damage require hepatic encephalopathy treatment, according to the National Center for Biotechnology Information (NCBI), and treatment may be delayed owing to the pandemic. Although, due to the lack of antibiotics, laxatives, and other medications, as well as erratic supply and transportation of medicine during the COVID-19 pandemic, the treatment of severe liver damage patients is postponed or even cancelled.

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Furthermore, the COVID-19 pandemic has disrupted the global drug supply, according to the US Food and Drug Administration (FDA), due to government-mandated or recommended temporary shutdowns, safety initiatives to ensure employee health and well-being, insufficient labor force, and restrictions on import and export activities, as well as travel. Antibiotic production has long been a particularly affected.

Clinical studies for the development of novel medications for hepatic encephalopathy are projected to fuel growth of the worldwide hepatic encephalopathy market throughout the forecast period, according to key competitors. Mallinckrodt Pharmaceuticals, for example, conducted clinical trials in 2019 for MNK-6105 (ornithine phenylacetate) intravenous and MNK-6106 (ornithine phenylacetate) oral drugs to prevent chronic hepatic encephalopathy recurrence. Currently, the trial is in its third phase.

Key Takeaways:

Due to expansion in promising markets, particularly in Europe, the worldwide hepatic encephalopathy market is predicted to increase at a CAGR of 5.3 percent over the projected period (2020-2027). North America accounted for the major share of the market.

The worldwide hepatic encephalopathy market is predicted to rise due to the rising availability of lactulose for the treatment of hepatic encephalopathy. For example, in April 2017, Cumberland Pharmaceuticals, a specialty pharmaceutical company based in the United States, and Poly Pharmaceuticals Inc., a privately held specialty pharmaceutical company based in the United States, signed an agreement to promote the Kristalose (lactulose solution for the treatment of hepatic encephalopathy) developed by Poly Pharmaceuticals Inc. in the United States. Kristalose’s present sales will be increased in the United States as a result of this multi-year co-promotion collaboration.

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Major Players Are: ASKA Pharmaceutical Co., Ltd., Cosmo Pharmaceuticals N.V., Lupin Limited, Kaleido Biosciences, Kannalife Sciences, Inc., Bausch Health Companies Inc., Ferring Pharmaceuticals Inc., Mallinckrodt Pharmaceuticals, Umecrine Cognition AB, Norgine B.V., Abbott Laboratories, and QR Science and Technology Development Co. Ltd.

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Frequently Asked Questions

What is the projected growth of the hepatic encephalopathy market?
The global hepatic encephalopathy market is estimated to grow by US$ 355.4 million during the period from 2021 to 2027.
How has COVID-19 affected the hepatic encephalopathy market?
The COVID-19 pandemic has slowed the hepatic encephalopathy market due to disruptions in drug supply and the impact on patients requiring treatment.
What factors are driving the growth of the hepatic encephalopathy market?
The increasing prevalence of risk factors such as hepatitis C and hepatic cirrhosis, along with clinical studies for novel medications, are expected to fuel market growth.
Who are the major players in the hepatic encephalopathy market?
Key players include ASKA Pharmaceutical Co., Ltd., Cosmo Pharmaceuticals N.V., Lupin Limited, and Ferring Pharmaceuticals Inc.
What is the expected CAGR for the hepatic encephalopathy market?
The worldwide hepatic encephalopathy market is predicted to increase at a CAGR of 5.3 percent over the projected period from 2020 to 2027.

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